As of 2021, over 4.9 million US women have used medication abortion with mifepristone and misoprostol since Mifeprex (mifepristone 200 mg) was first approved by the US Food and Drug Administration (FDA) in 2000.
An updated review of the data shows that medication abortion continues to be very safe. In fact, it is safer than continuing a pregnancy to term or using other common medications administered in outpatient settings, such as penicillin, Viagra, or Tylenol.